Reaction Details |
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Target | Nuclear receptor subfamily 1 group I member 2 |
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Ligand | BDBM50204072 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1626059 (CHEMBL3868528) |
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EC50 | 1000±n/a nM |
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Citation | Kick, EK; Busch, BB; Martin, R; Stevens, WC; Bollu, V; Xie, Y; Boren, BC; Nyman, MC; Nanao, MH; Nguyen, L; Plonowski, A; Schulman, IG; Yan, G; Zhang, H; Hou, X; Valente, MN; Narayanan, R; Behnia, K; Rodrigues, AD; Brock, B; Smalley, J; Cantor, GH; Lupisella, J; Sleph, P; Grimm, D; Ostrowski, J; Wexler, RR; Kirchgessner, T; Mohan, R Discovery of Highly Potent Liver X Receptorß Agonists. ACS Med Chem Lett7:1207-1212 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nuclear receptor subfamily 1 group I member 2 |
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Name: | Nuclear receptor subfamily 1 group I member 2 |
Synonyms: | NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 |
Type: | Nuclear receptor |
Mol. Mass.: | 49774.77 |
Organism: | Homo sapiens (Human) |
Description: | O75469 |
Residue: | 434 |
Sequence: | MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
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BDBM50204072 |
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n/a |
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Name | BDBM50204072 |
Synonyms: | CHEMBL3945199 | US10543183, Compound 12 | US10945978, Compound 12 |
Type | Small organic molecule |
Emp. Form. | C29H28Cl2F2N2O4S |
Mol. Mass. | 609.511 |
SMILES | CC(C)(O)c1cn(c(n1)C(C)(C)c1c(Cl)cccc1Cl)-c1ccc(cc1F)-c1cc(F)c(CO)c(c1)S(C)(=O)=O |
Structure |
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