| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Androgen receptor |
|---|
| Ligand | BDBM50204241 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1627004 (CHEMBL3869525) |
|---|
| Ki | 3.0±n/a nM |
|---|
| Citation |  Shan, W; Balog, A; Nation, A; Zhu, X; Chen, J; Cvijic, ME; Geng, J; Rizzo, CA; Spires, T; Attar, RM; Obermeier, M; Traeger, S; Dai, J; Zhang, Y; Galella, M; Trainor, G; Vite, GD; Gavai, AV [2.2.1]-Bicyclic sultams as potent androgen receptor antagonists. Bioorg Med Chem Lett26:5707-5711 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Androgen receptor |
|---|
| Name: | Androgen receptor |
|---|
| Synonyms: | ANDR_HUMAN | AR | Androgen Receptor | Androgen receptor (AR) | Androgen receptor/Baculoviral IAP repeat-containing protein 2 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 |
|---|
| Type: | Receptor |
|---|
| Mol. Mass.: | 99185.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | CHO cells were stably transfected with human AR gene.
|
|---|
| Residue: | 920 |
|---|
| Sequence: | MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQ
QQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQ
SALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSAD
LKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELC
KAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAG
KSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQ
SRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAA
GPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAP
YGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRL
ETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRN
DCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKL
TVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA
KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSR
MYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELD
RIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEII
SVQVPKILSGKVKPIYFHTQ
|
|
|
|---|
| BDBM50204241 |
|---|
| n/a |
|---|
| Name | BDBM50204241 |
|---|
| Synonyms: | CHEMBL3917372 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H15F3N2O2S |
|---|
| Mol. Mass. | 356.363 |
|---|
| SMILES | [H][C@]12CC[C@]([H])(C1)[C@]1([H])[C@@]2([H])CN(c2ccc(C#N)c(c2)C(F)(F)F)S1(=O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
