| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 6 |
|---|
| Ligand | BDBM50204257 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1627040 (CHEMBL3869561) |
|---|
| IC50 | 3300±n/a nM |
|---|
| Citation |  Dressman, BA; Tromiczak, EG; Chappell, MD; Tripp, AE; Quimby, SJ; Vetman, T; Fivush, AM; Matt, J; Jaramillo, C; Li, R; Khilevich, A; Blanco, MJ; Smith, SC; Carpintero, M; de Diego, JE; Barberis, M; García-Cerrada, S; Soriano, JF; Schkeryantz, JM; Witkin, JM; Wafford, KA; Seidel, W; Britton, T; Overshiner, CD; Li, X; Wang, XS; Heinz, BA; Catlow, JT; Swanson, S; Bedwell, D; Ornstein, PL; Mitch, CH Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression. Bioorg Med Chem Lett26:5663-5668 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 6 |
|---|
| Name: | Metabotropic glutamate receptor 6 |
|---|
| Synonyms: | GPRC1F | GRM6 | GRM6_HUMAN | MGLUR6 | Metabotropic glutamate receptor 6 | glutamate receptor, metabotropic 6 precursor | metabotropic glutamate 6 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 95479.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | metabotropic glutamate 6 GRM6 HUMAN::O15303 |
|---|
| Residue: | 877 |
|---|
| Sequence: | MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQL
KKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGR
GDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE
LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA
GGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGH
FLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEF
WEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQ
ALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG
SASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHC
EACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVAT
TTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLG
TTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARP
PHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFN
EAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKT
YVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
|
|
|
|---|
| BDBM50204257 |
|---|
| n/a |
|---|
| Name | BDBM50204257 |
|---|
| Synonyms: | CHEMBL3947221 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H15Cl2NO6 |
|---|
| Mol. Mass. | 376.189 |
|---|
| SMILES | [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@H]2O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
