Ki Summary

Reaction Details

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Target

Inward rectifier potassium channel 13

Ligand

BDBM50204281

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1627131 (CHEMBL3869652)

IC50

>100000±n/a nM

Citation

Zhu, Y; de Jesus, RK; Tang, H; Walsh, SP; Jiang, J; Gu, X; Teumelsan, N; Shahripour, A; Pio, B; Ding, FX; Ha, S; Priest, BT; Swensen, AM; Alonso-Galicia, M; Felix, JP; Brochu, RM; Bailey, T; Thomas-Fowlkes, B; Zhou, X; Pai, LY; Hampton, C; Hernandez, M; Owens, K; Ehrhart, J; Roy, S; Kaczorowski, GJ; Yang, L; Parmee, ER; Sullivan, K; Garcia, ML; Pasternak, A Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold. Bioorg Med Chem Lett26:5695-5702 (2016) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Inward rectifier potassium channel 13

Name:

Inward rectifier potassium channel 13

Synonyms:

Inward rectifier K(+) channel Kir7.1 | KCJ13_HUMAN | KCNJ13 | Potassium channel, inwardly rectifying subfamily J member 13

Type:

PROTEIN

Mol. Mass.:

40527.12

Organism:

Homo sapiens (Human)

Description:

ChEMBL_105176

Residue:

360

Sequence:

MDSSNCKVIAPLLSQRYRRMVTKDGHSTLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVF
SASFVVHWLVFAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTI
GYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAH
MDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGKLYQTSVDFHLDGISSDECPFFIFP
LTYYHSITPSSPLATLLQHENPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHCFA
SLLTRGSKGEYQIKMENFDKTVPEFPTPLVSKSPNRTDLDIHINGQSIDNFQISETGLTE

BDBM50204281

n/a

Name

BDBM50204281

Synonyms:

CHEMBL3933749

Type

Small organic molecule

Emp. Form.

C23H23FN8O2

Mol. Mass.

462.4795

SMILES

[H][C@]12CO[C@@H](CN1CCN(C2)C(=O)Cc1ccc(cn1)-n1cnnn1)c1ccc(F)c(C#N)c1C |r|

Structure