Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetATP-sensitive inward rectifier potassium channel 1
LigandBDBM50204284
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1627126 (CHEMBL3869647)
IC50 107±n/a nM
Citation Zhu, Yde Jesus, RKTang, HWalsh, SPJiang, JGu, XTeumelsan, NShahripour, APio, BDing, FXHa, SPriest, BTSwensen, AMAlonso-Galicia, MFelix, JPBrochu, RMBailey, TThomas-Fowlkes, BZhou, XPai, LYHampton, CHernandez, MOwens, KEhrhart, JRoy, SKaczorowski, GJYang, LParmee, ERSullivan, KGarcia, MLPasternak, A Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold. Bioorg Med Chem Lett26:5695-5702 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
ATP-sensitive inward rectifier potassium channel 1
Name:ATP-sensitive inward rectifier potassium channel 1
Synonyms:ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:Enzyme Catalytic Domain
Mol. Mass.:44809.08
Organism:Homo sapiens (Human)
Description:gi_223460826
Residue:391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50204284
n/a
NameBDBM50204284
Synonyms:CHEMBL3928945
TypeSmall organic molecule
Emp. Form.C22H22FN9O2
Mol. Mass.463.4676
SMILES[H][C@]12CO[C@H](CN1CCN(C2)C(=O)Cc1cnc(cn1)-n1cnnn1)c1ccc(F)c(C#N)c1C |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: