| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-galactosidase A |
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| Ligand | BDBM50099009 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1627785 (CHEMBL3870370) |
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| pH | 7±n/a |
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| IC50 | 53±n/a nM |
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| Comments | extracted |
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| Citation |  Cheng, WC; Wang, JH; Li, HY; Lu, SJ; Hu, JM; Yun, WY; Chiu, CH; Yang, WB; Chien, YH; Hwu, WL Bioevaluation of sixteen ADMDP stereoisomers toward alpha-galactosidase A: Development of a new pharmacological chaperone for the treatment of Fabry disease and potential enhancement of enzyme replacement therapy efficiency. Eur J Med Chem123:14-20 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-galactosidase A |
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| Name: | Alpha-galactosidase A |
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| Synonyms: | AGAL_HUMAN | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A) | GLA | INN=Agalsidase | Melibiase |
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| Type: | Protein |
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| Mol. Mass.: | 48760.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 429 |
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| Sequence: | MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEP
DSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQL
ANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENL
ADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIK
SILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDL
RHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIG
GPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENT
MQMSLKDLL
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| BDBM50099009 |
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| n/a |
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| Name | BDBM50099009 |
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| Synonyms: | (3S,4S,5R)-2-Aminomethyl-5-hydroxymethyl-pyrrolidine-3,4-diol | BDBM50204612 | CHEMBL3350086 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H14N2O3 |
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| Mol. Mass. | 162.187 |
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| SMILES | NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O |
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| Structure | 
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