| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50205358 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1628377 (CHEMBL3870962) |
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| Ki | 13±n/a nM |
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| Citation |  Procopiou, PA; Ancliff, RA; Gore, PM; Hancock, AP; Hodgson, ST; Holmes, DS; Keeling, SP; Looker, BE; Parr, NA; Rowedder, JE; Slack, RJ The discovery of quinoline based single-ligand human H Bioorg Med Chem Lett26:5855-5859 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55808.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
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| Residue: | 487 |
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| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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| BDBM50205358 |
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| n/a |
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| Name | BDBM50205358 |
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| Synonyms: | CHEMBL3898341 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H52N4O3 |
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| Mol. Mass. | 600.8338 |
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| SMILES | CCCCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(O)=O)ccc2c1 |
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| Structure | 
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