Reaction Details |
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Target | Histone-lysine N-methyltransferase EZH1 |
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Ligand | BDBM50205639 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1628507 (CHEMBL3871092) |
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IC50 | 3340±n/a nM |
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Citation | Ansari, A; Satalkar, S; Patil, V; Shete, AS; Kaur, S; Gupta, A; Singh, S; Raja, M; Severance, DL; Bernales, S; Chakravarty, S; Hung, DT; Pham, SM; Herrera, FJ; Rai, R Novel 3-methylindoline inhibitors of EZH2: Design, synthesis and SAR. Bioorg Med Chem Lett27:217-222 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone-lysine N-methyltransferase EZH1 |
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Name: | Histone-lysine N-methyltransferase EZH1 |
Synonyms: | ENX-2 | EZH1 | EZH1_HUMAN | Enhancer of zeste homolog 1 | Enhancer of zeste homolog 1 (EZH1) | Histone-lysine N-methyltransferase EZH1 | KIAA0388 |
Type: | Protein |
Mol. Mass.: | 85285.34 |
Organism: | Homo sapiens (Human) |
Description: | Q92800 |
Residue: | 747 |
Sequence: | MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAI
ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
RRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
EELFFDYRYSQADALKYVGIERETDVL
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BDBM50205639 |
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n/a |
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Name | BDBM50205639 |
Synonyms: | CHEMBL3892623 |
Type | Small organic molecule |
Emp. Form. | C34H42N4O4 |
Mol. Mass. | 570.7217 |
SMILES | CC1CN(C2CCOCC2)c2cc(cc(C(=O)NCc3c(C)cc(C)[nH]c3=O)c12)-c1ccc(CN2CCOCC2)cc1 |
Structure |
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