| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tryptophan 2,3-dioxygenase |
|---|
| Ligand | BDBM50205803 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1628532 (CHEMBL3871117) |
|---|
| IC50 | 58±n/a nM |
|---|
| Citation |  Abdel-Magid, AF Targeting the Inhibition of Tryptophan 2,3-Dioxygenase (TDO-2) for Cancer Treatment. ACS Med Chem Lett8:11-13 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tryptophan 2,3-dioxygenase |
|---|
| Name: | Tryptophan 2,3-dioxygenase |
|---|
| Synonyms: | T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47874.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_825691 |
|---|
| Residue: | 406 |
|---|
| Sequence: | MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
|
|
|
|---|
| BDBM50205803 |
|---|
| n/a |
|---|
| Name | BDBM50205803 |
|---|
| Synonyms: | CHEMBL3975938 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20FN3O4S |
|---|
| Mol. Mass. | 429.465 |
|---|
| SMILES | CC1N(CC2(C)COC(=O)N2)S(=O)(=O)c2ccc(cc12)-c1c[nH]c2cc(F)ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
