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TargetCoagulation factor VII/Tissue factor
LigandBDBM50205826
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1628565 (CHEMBL3871150)
Ki 23±n/a nM
Citation Richter, JMCheney, DLBates, JAWei, ALuettgen, JMRendina, ARHarper, TMNarayanan, RWong, PCSeiffert, DWexler, RRPriestley, ES Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors. ACS Med Chem Lett8:67-72 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor VII/Tissue factor
Name:Coagulation factor VII/Tissue factor
Synonyms:Coagulation factor III/Factor VIIa (fVIIa) | Coagulation factor III/VII
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 69535
Components:This complex has 2 components.
Component 1
Name:Tissue factor
Synonyms:CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor
Type:PROTEIN
Mol. Mass.:33067.61
Organism:Homo sapiens (Human)
Description:ChEMBL_936735
Residue:295
Sequence:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
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Component 2
Name:Coagulation factor VII
Synonyms:Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:Enzyme
Mol. Mass.:51599.89
Organism:Homo sapiens (Human)
Description:n/a
Residue:466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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BDBM50205826
n/a
NameBDBM50205826
Synonyms:CHEMBL3941720
TypeSmall organic molecule
Emp. Form.C32H33N5O6S
Mol. Mass.615.699
SMILESCOc1ccc2cc1COCC(=O)Nc1ccc(c(CN(C)C(=O)[C@@H]2Nc2ccc3c(N)nccc3c2)c1)S(=O)(=O)C1CC1 |r|
Structure
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