Reaction Details |
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Target | Vitamin K-dependent protein C |
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Ligand | BDBM50205841 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1628573 (CHEMBL3871158) |
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Ki | 39±n/a nM |
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Citation | Richter, JM; Cheney, DL; Bates, JA; Wei, A; Luettgen, JM; Rendina, AR; Harper, TM; Narayanan, R; Wong, PC; Seiffert, D; Wexler, RR; Priestley, ES Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors. ACS Med Chem Lett8:67-72 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Vitamin K-dependent protein C |
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Name: | Vitamin K-dependent protein C |
Synonyms: | Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor |
Type: | Enzyme |
Mol. Mass.: | 52067.73 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 461 |
Sequence: | MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
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BDBM50205841 |
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n/a |
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Name | BDBM50205841 |
Synonyms: | CHEMBL3898956 |
Type | Small organic molecule |
Emp. Form. | C34H34F3N5O5S |
Mol. Mass. | 681.724 |
SMILES | C[C@@H]1CC(=O)Nc2ccc(c(CN(C)C(=O)[C@H](Nc3ccc4c(N)ncc(F)c4c3)c3ccc(OCC(F)F)c1c3)c2)S(=O)(=O)C1CC1 |r| |
Structure |
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