| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM50205841 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1628568 (CHEMBL3871153) |
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| Ki | 9.4±n/a nM |
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| Citation |  Richter, JM; Cheney, DL; Bates, JA; Wei, A; Luettgen, JM; Rendina, AR; Harper, TM; Narayanan, R; Wong, PC; Seiffert, D; Wexler, RR; Priestley, ES Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors. ACS Med Chem Lett8:67-72 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM50205841 |
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| n/a |
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| Name | BDBM50205841 |
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| Synonyms: | CHEMBL3898956 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H34F3N5O5S |
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| Mol. Mass. | 681.724 |
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| SMILES | C[C@@H]1CC(=O)Nc2ccc(c(CN(C)C(=O)[C@H](Nc3ccc4c(N)ncc(F)c4c3)c3ccc(OCC(F)F)c1c3)c2)S(=O)(=O)C1CC1 |r| |
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| Structure | 
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