| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid 21-hydroxylase |
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| Ligand | BDBM50206963 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1629495 (CHEMBL3872121) |
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| IC50 | >10000±n/a nM |
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| Citation |  Whitehead, BR; Lo, MM; Ali, A; Park, MK; Hoyt, SB; Xiong, Y; Cai, J; Carswell, E; Cooke, A; MacLean, J; Ratcliffe, P; Robinson, J; Bennett, DJ; Clemas, JA; Wisniewski, T; Struthers, M; Cully, D; MacNeil, DJ Imidazopyridyl compounds as aldosterone synthase inhibitors. Bioorg Med Chem Lett27:143-146 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Steroid 21-hydroxylase |
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| Name: | Steroid 21-hydroxylase |
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| Synonyms: | CP21A_HUMAN | CYP21 | CYP21A2 | CYP21B | Cytochrome P450 21 | Cytochrome P450 21A2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55896.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1498865 |
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| Residue: | 494 |
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| Sequence: | MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAHK
KLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDK
IKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQ
LRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTL
SWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVP
LALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRL
QPRGMGAHSPGQNQ
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| BDBM50206963 |
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| n/a |
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| Name | BDBM50206963 |
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| Synonyms: | CHEMBL3948337 | US9518055, Example 41 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14FN3 |
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| Mol. Mass. | 303.333 |
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| SMILES | Fc1ccc2nc(c(C3CC3)n2c1)-c1cncc2ccccc12 |
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| Structure | 
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