| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-tyrosine kinase 2-beta |
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| Ligand | BDBM50207351 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1630970 (CHEMBL3873676) |
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| IC50 | 20±n/a nM |
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| Citation |  Farand, J; Mai, N; Chandrasekhar, J; Newby, ZE; Van Veldhuizen, J; Loyer-Drew, J; Venkataramani, C; Guerrero, J; Kwok, A; Li, N; Zherebina, Y; Wilbert, S; Zablocki, J; Phillips, G; Watkins, WJ; Mourey, R; Notte, GT Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency. Bioorg Med Chem Lett26:5926-5930 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-tyrosine kinase 2-beta |
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| Name: | Protein-tyrosine kinase 2-beta |
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| Synonyms: | FAK2 | FAK2_HUMAN | PTK2B | PTK2B protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta (PTK2B) | PYK2 | Protein tyrosine kinase 2 beta | RAFTK |
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| Type: | Protein |
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| Mol. Mass.: | 115868.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14289 |
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| Residue: | 1009 |
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| Sequence: | MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA
EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG
SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI
AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN
LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL
ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR
CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP
KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR
EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP
LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ
LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA
QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
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| BDBM50207351 |
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| n/a |
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| Name | BDBM50207351 |
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| Synonyms: | CHEMBL3965256 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27BrF3N7O3S |
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| Mol. Mass. | 642.491 |
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| SMILES | CS(=O)(=O)N(CC=C)c1ncccc1CNc1nc(Nc2ccc(N3CCOCC3)c(Br)c2)ncc1C(F)(F)F |
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| Structure | 
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