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TargetCysteinyl leukotriene receptor 1
LigandBDBM50207402
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1631170 (CHEMBL3873876)
IC50 390±n/a nM
Citation Blanco, MJBenesh, DRKnobelsdorf, JAKhilevich, ACortez, GSMokube, FAicher, TDGroendyke, TMMarmsater, FPTang, TPJohnson, KWClemens-Smith, AMuhlhauser, MASwanson, SCatlow, JEmkey, RJohnson, MPSchkeryantz, JM Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache. Bioorg Med Chem Lett27:323-328 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cysteinyl leukotriene receptor 1
Name:Cysteinyl leukotriene receptor 1
Synonyms:CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1
Type:Enzyme Catalytic Domain
Mol. Mass.:38565.16
Organism:Homo sapiens (Human)
Description:Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271
Residue:337
Sequence:
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
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  Blast E-value cutoff:
BDBM50207402
n/a
NameBDBM50207402
Synonyms:CHEMBL3980125
TypeSmall organic molecule
Emp. Form.C24H23N5O4
Mol. Mass.445.4705
SMILESCCCc1c(OCc2cccc(Oc3ncccc3-c3nn[nH]n3)c2)ccc(C(C)=O)c1O
Structure
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