| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 5A |
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| Ligand | BDBM50207400 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1631229 (CHEMBL3873935) |
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| Ki | >6900000±n/a nM |
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| Citation |  Blanco, MJ; Benesh, DR; Knobelsdorf, JA; Khilevich, A; Cortez, GS; Mokube, F; Aicher, TD; Groendyke, TM; Marmsater, FP; Tang, TP; Johnson, KW; Clemens-Smith, A; Muhlhauser, MA; Swanson, S; Catlow, J; Emkey, R; Johnson, MP; Schkeryantz, JM Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache. Bioorg Med Chem Lett27:323-328 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 5A |
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| Name: | 5-hydroxytryptamine receptor 5A |
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| Synonyms: | 5-HT-5 | 5-HT-5A | 5-hydroxytryptamine receptor 5 (5-HT5) | 5-hydroxytryptamine receptor 5A (5-HT5A) | 5HT5A_HUMAN | HTR5A | Serotonin (5-HT) receptor | Serotonin receptor 5A |
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| Type: | Enzyme |
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| Mol. Mass.: | 40266.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47898 |
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| Residue: | 357 |
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| Sequence: | MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL
VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC
DVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFG
WGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVS
PISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIP
FFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
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| BDBM50207400 |
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| n/a |
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| Name | BDBM50207400 |
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| Synonyms: | CHEMBL3899832 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N5O4 |
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| Mol. Mass. | 417.4174 |
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| SMILES | CC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O |
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| Structure | 
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