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TargetMetabotropic glutamate receptor 3
LigandBDBM50207400
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1631192 (CHEMBL3873898)
EC50>25000±n/a nM
Citation Blanco, MJBenesh, DRKnobelsdorf, JAKhilevich, ACortez, GSMokube, FAicher, TDGroendyke, TMMarmsater, FPTang, TPJohnson, KWClemens-Smith, AMuhlhauser, MASwanson, SCatlow, JEmkey, RJohnson, MPSchkeryantz, JM Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache. Bioorg Med Chem Lett27:323-328 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Metabotropic glutamate receptor 3
Name:Metabotropic glutamate receptor 3
Synonyms:GPRC1C | GRM3 | GRM3_HUMAN | MGLUR3 | metabotropic glutamate 3 | metabotropic glutamate 3/1a | metabotropic glutamate 3/1c
Type:Enzyme Catalytic Domain
Mol. Mass.:98889.09
Organism:Homo sapiens (Human)
Description:metabotropic glutamate 1c 0 HUMAN::Q14832
Residue:879
Sequence:
MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY
LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA
EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH
LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50207400
n/a
NameBDBM50207400
Synonyms:CHEMBL3899832
TypeSmall organic molecule
Emp. Form.C22H19N5O4
Mol. Mass.417.4174
SMILESCC(=O)c1ccc(OCc2ccc(Oc3cc(ccn3)-c3nn[nH]n3)cc2)c(C)c1O
Structure
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