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TargetMuscarinic acetylcholine receptor M4
LigandBDBM50207521
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1631985 (CHEMBL3874691)
EC50 45±n/a nM
Citation Wood, MRNoetzel, MJPoslusney, MSMelancon, BJTarr, JCLamsal, AChang, SLuscombe, VBWeiner, RLCho, HPBubser, MJones, CKNiswender, CMWood, MWEngers, DWBrandon, NJDuggan, MEConn, PJBridges, TMLindsley, CW Challenges in the development of an M Bioorg Med Chem Lett27:171-175 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M4
Name:Muscarinic acetylcholine receptor M4
Synonyms:ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:Enzyme Catalytic Domain
Mol. Mass.:52841.70
Organism:RAT
Description:Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ
LQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMN
LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD
NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL
AFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSAT
QNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPA
TPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLV
NTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50207521
n/a
NameBDBM50207521
Synonyms:CHEMBL3955059
TypeSmall organic molecule
Emp. Form.C20H24N4O3S2
Mol. Mass.432.56
SMILESCc1nnc2sc(C(=O)NCc3ccc(cc3)S(=O)(=O)C(C)(C)C)c(N)c2c1C
Structure
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