Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50207818 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1632260 (CHEMBL3874966) |
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Ki | 1.5±n/a nM |
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Citation | Ivanova, J; Balode, A; ?alubovskis, R; Leitans, J; Kazaks, A; Vullo, D; Tars, K; Supuran, CT 5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations. Bioorg Med Chem25:857-863 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50207818 |
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n/a |
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Name | BDBM50207818 |
Synonyms: | CHEMBL3956725 |
Type | Small organic molecule |
Emp. Form. | C12H10F3NO2S3 |
Mol. Mass. | 353.404 |
SMILES | NS(=O)(=O)c1ccc(SCc2ccc(cc2)C(F)(F)F)s1 |
Structure |
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