Reaction Details |
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Target | Acetylcholinesterase |
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Ligand | BDBM50208256 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1632485 (CHEMBL3875277) |
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IC50 | 9.7±n/a nM |
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Citation | Wieckowska, A; Kolaczkowski, M; Bucki, A; Godyn, J; Marcinkowska, M; Wieckowski, K; Zareba, P; Siwek, A; Kazek, G; Gluch-Lutwin, M; Mierzejewski, P; Bienkowski, P; Sienkiewicz-Jarosz, H; Knez, D; Wichur, T; Gobec, S; Malawska, B Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT Eur J Med Chem124:63-81 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acetylcholinesterase |
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Name: | Acetylcholinesterase |
Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
Type: | Enzyme |
Mol. Mass.: | 67792.70 |
Organism: | Homo sapiens (Human) |
Description: | P22303 |
Residue: | 614 |
Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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BDBM50208256 |
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n/a |
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Name | BDBM50208256 |
Synonyms: | CHEMBL3884618 |
Type | Small organic molecule |
Emp. Form. | C34H37N5O2S |
Mol. Mass. | 579.755 |
SMILES | O=S(=O)(c1ccccc1)n1ccc2c(cccc12)N1CCN(CCCNc2c3CCCCc3nc3ccccc23)CC1 |
Structure |
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