| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM50208252 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1632481 (CHEMBL3875273) |
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| IC50 | 608±n/a nM |
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| Citation |  Wieckowska, A; Kolaczkowski, M; Bucki, A; Godyn, J; Marcinkowska, M; Wieckowski, K; Zareba, P; Siwek, A; Kazek, G; Gluch-Lutwin, M; Mierzejewski, P; Bienkowski, P; Sienkiewicz-Jarosz, H; Knez, D; Wichur, T; Gobec, S; Malawska, B Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT Eur J Med Chem124:63-81 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase |
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| Type: | Enzyme |
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| Mol. Mass.: | 65643.35 |
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| Organism: | Equus caballus (Horse) |
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| Description: | P81908 |
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| Residue: | 574 |
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| Sequence: | EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATK
YANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQT
GTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQK
NIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEAR
NRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLT
DMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPR
VSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYY
FEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNP
NGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAE
REWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
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| BDBM50208252 |
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| n/a |
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| Name | BDBM50208252 |
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| Synonyms: | CHEMBL3884154 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H32N4O2S |
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| Mol. Mass. | 488.644 |
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| SMILES | O=S(=O)(c1ccccc1)n1ccc2c(cccc12)N1CCN(CCCNCc2ccccc2)CC1 |
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| Structure | 
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