| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B |
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| Ligand | BDBM50208315 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1632642 (CHEMBL3875434) |
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| IC50 | >100000±n/a nM |
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| Citation |  Zhou, ZZ; Ge, BC; Zhong, QP; Huang, C; Cheng, YF; Yang, XM; Wang, HT; Xu, JP Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings. Eur J Med Chem124:372-379 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B |
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| Name: | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B |
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| Synonyms: | CGI-PDE B | CGIP1 | CGIPDE1 | Cyclic GMP-inhibited phosphodiesterase B | PDE3B | PDE3B_HUMAN | Phosphodiesterase 3B | Phosphodiesterase 3B (PDE3B) | Phosphodiesterase Type 3 (PDE3B) | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | cGMP-inhibited 3,5-cyclic phosphodiesterase B |
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| Type: | Enzyme |
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| Mol. Mass.: | 124318.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PDE3B was generated from the full-length recombinant human clone transfected into Sf9 cells. |
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| Residue: | 1112 |
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| Sequence: | MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELR
PPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSLS
PLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGD
AGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSL
PSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVSL
GETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEAR
NMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKG
DRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGP
FNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDT
ADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSG
KSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLD
LILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQF
MNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRIN
HGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQ
AVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFD
FLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFY
EQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDN
DTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEE
KCKADGNKLQVENSSLPQADEIQVIEEADEEE
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| BDBM50208315 |
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| n/a |
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| Name | BDBM50208315 |
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| Synonyms: | CHEMBL3884224 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16F2N2O3 |
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| Mol. Mass. | 334.3173 |
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| SMILES | FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1cccnc1 |
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| Structure | 
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