| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
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| Ligand | BDBM50208310 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1632640 (CHEMBL3875432) |
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| IC50 | >100000±n/a nM |
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| Citation |  Zhou, ZZ; Ge, BC; Zhong, QP; Huang, C; Cheng, YF; Yang, XM; Wang, HT; Xu, JP Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings. Eur J Med Chem124:372-379 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
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| Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
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| Synonyms: | 61 kDa Cam-PDE | Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A | Cam-PDE 1A | PDE1A | PDE1A_HUMAN | hCam-1 |
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| Type: | Protein |
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| Mol. Mass.: | 61245.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54750 |
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| Residue: | 535 |
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| Sequence: | MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA
SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS
IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI
YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL
ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS
MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ
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| BDBM50208310 |
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| n/a |
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| Name | BDBM50208310 |
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| Synonyms: | CHEMBL3883753 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18ClF2NO3 |
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| Mol. Mass. | 381.801 |
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| SMILES | FC(F)Oc1ccc(cc1OC1CCCC1)C(=O)Nc1ccccc1Cl |
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| Structure | 
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