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TargetPhosphodiesterase 7
LigandBDBM50208311
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1632650
IC50>1±n/a nM
Citation Zhou ZZGe BCZhong QPHuang CCheng YFYang XMWang HTXu JP Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings. Eur J Med Chem 124:372-379 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Phosphodiesterase 7
Name:3',5'-cyclic phosphodiesterase
Synonyms:Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:Enzyme
Mol. Mass.:55514.96
Organism:Homo sapiens (Human)
Description:Q13946
Residue:482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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  Blast E-value cutoff:
BDBM50208311
n/a
NameBDBM50208311
Synonyms:CHEMBL3885161
TypeSmall organic molecule
Emp. Form.C18H18F2N2O3
Mol. Mass.348.3439
SMILESFC(F)Oc1ccc(cc1OC1CCCC1)C(=O)Nc1cccnc1
Structure
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