| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
|---|
| Ligand | BDBM50208315 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1632649 (CHEMBL3875441) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Zhou, ZZ; Ge, BC; Zhong, QP; Huang, C; Cheng, YF; Yang, XM; Wang, HT; Xu, JP Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings. Eur J Med Chem124:372-379 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
|---|
| Name: | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE6C | PDE6C_HUMAN | PDEA2 | Phosphodiesterase 6C | Phosphodiesterase 6C (PDE6C) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 99132.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51160 |
|---|
| Residue: | 858 |
|---|
| Sequence: | MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA
LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT
SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL
ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS
QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE
VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN
MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY
ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD
VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV
PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF
CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET
VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT
ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI
DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA
AEDSGGGDDKKSKTCLML
|
|
|
|---|
| BDBM50208315 |
|---|
| n/a |
|---|
| Name | BDBM50208315 |
|---|
| Synonyms: | CHEMBL3884224 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H16F2N2O3 |
|---|
| Mol. Mass. | 334.3173 |
|---|
| SMILES | FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
