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TargetDual specificity mitogen-activated protein kinase kinase 6
LigandBDBM50208911
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1633316 (CHEMBL3876108)
IC50 10000±n/a nM
Citation Katz, JDHaidle, AChilders, KKZabierek, AAJewell, JPHou, YAltman, MDSzewczak, AChen, DHarsch, AHayashi, MWarren, LHutton, MNuthall, HSu, HPMunshi, SStanton, MGDavies, IWMunoz, BNorthrup, A Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors. Bioorg Med Chem Lett27:114-120 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity mitogen-activated protein kinase kinase 6
Name:Dual specificity mitogen-activated protein kinase kinase 6
Synonyms:Dual specificity mitogen-activated protein kinase kinase 6 | MAP kinase kinase 6 | MAP2K6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK6 | MKK6 | MP2K6_HUMAN | Mitogen-activated protein kinase kinase 6 (MKK6) | PRKMK6 | SAPKK3 | SKK3
Type:Protein
Mol. Mass.:37494.96
Organism:Homo sapiens (Human)
Description:P52564
Residue:334
Sequence:
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG
RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF
REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK
ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
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  Blast E-value cutoff:
BDBM50208911
n/a
NameBDBM50208911
Synonyms:CHEMBL3884319
TypeSmall organic molecule
Emp. Form.C23H22N4O2
Mol. Mass.386.4464
SMILESCC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3ccccc3)ncc12 |r|
Structure
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