| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase II subunit alpha |
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| Ligand | BDBM50208911 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1633282 (CHEMBL3876074) |
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| IC50 | 10000±n/a nM |
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| Citation |  Katz, JD; Haidle, A; Childers, KK; Zabierek, AA; Jewell, JP; Hou, Y; Altman, MD; Szewczak, A; Chen, D; Harsch, A; Hayashi, M; Warren, L; Hutton, M; Nuthall, H; Su, HP; Munshi, S; Stanton, MG; Davies, IW; Munoz, B; Northrup, A Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors. Bioorg Med Chem Lett27:114-120 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase II subunit alpha |
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| Name: | Casein kinase II subunit alpha |
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| Synonyms: | CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a) |
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| Type: | Enzyme |
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| Mol. Mass.: | 45151.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P68400 |
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| Residue: | 391 |
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| Sequence: | MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT
PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
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| BDBM50208911 |
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| n/a |
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| Name | BDBM50208911 |
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| Synonyms: | CHEMBL3884319 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N4O2 |
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| Mol. Mass. | 386.4464 |
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| SMILES | CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3ccccc3)ncc12 |r| |
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| Structure | 
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