Reaction Details |
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Target | MAP/microtubule affinity-regulating kinase 4 |
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Ligand | BDBM50208925 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1633232 (CHEMBL3876024) |
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IC50 | 5990±n/a nM |
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Citation | Katz, JD; Haidle, A; Childers, KK; Zabierek, AA; Jewell, JP; Hou, Y; Altman, MD; Szewczak, A; Chen, D; Harsch, A; Hayashi, M; Warren, L; Hutton, M; Nuthall, H; Su, HP; Munshi, S; Stanton, MG; Davies, IW; Munoz, B; Northrup, A Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors. Bioorg Med Chem Lett27:114-120 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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MAP/microtubule affinity-regulating kinase 4 |
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Name: | MAP/microtubule affinity-regulating kinase 4 |
Synonyms: | KIAA1860 | MAP/microtubule affinity-regulating kinase 4 | MARK4 | MARK4_HUMAN | MARKL1 |
Type: | PROTEIN |
Mol. Mass.: | 82561.08 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_774620 |
Residue: | 752 |
Sequence: | MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR
LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK
LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR
DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW
SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT
LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV
TATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR
RHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAH
NPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVP
PASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHE
AAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPW
SVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLP
RPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
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BDBM50208925 |
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n/a |
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Name | BDBM50208925 |
Synonyms: | CHEMBL3883548 |
Type | Small organic molecule |
Emp. Form. | C19H23N5O |
Mol. Mass. | 337.4188 |
SMILES | CC1(C)C(=O)N(C2CCCCC2)c2nc(Nc3cccnc3)ncc12 |
Structure |
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