Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCarbonic anhydrase 7
LigandBDBM50209226
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1633810
Ki 0.810000±n/a nM
Citation Angapelly SRamya PVAngeli AMonti SMBuonanno MAlvala MSupuran CTArifuddin M Discovery of 4-sulfamoyl-phenyl--lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors. Bioorg Med Chem 25:539-544 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 7
Name:Carbonic anhydrase
Synonyms:CA-VII | CA7 | Carbonate dehydratase VII | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:Enzyme
Mol. Mass.:29664.11
Organism:Homo sapiens (Human)
Description:Human cloned isozyme.
Residue:264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLS
ITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSEL
HLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSC
FNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDER
IHMVNNFRPPQPLKGRVVKASFRA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50209226
n/a
NameBDBM50209226
Synonyms:CHEMBL3884755
TypeSmall organic molecule
Emp. Form.C24H24N2O6S
Mol. Mass.468.522
SMILESCOc1ccc([C@H]2[C@@H](C(=O)N2c2ccc(cc2)S(N)(=O)=O)c2ccccc2)c(OC)c1OC |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: