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TargetMitogen-activated protein kinase kinase kinase 7
LigandBDBM50209673
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1633896 (CHEMBL3876688)
IC50 75±n/a nM
Citation Tan, LGurbani, DWeisberg, ELHunter, JCLi, LJones, DSFicarro, SBMowafy, STam, CPRao, SDu, GGriffin, JDSorger, PKMarto, JAWestover, KDGray, NS Structure-guided development of covalent TAK1 inhibitors. Bioorg Med Chem25:838-846 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase kinase kinase 7
Name:Mitogen-activated protein kinase kinase kinase 7
Synonyms:M3K7_HUMAN | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | TAK1 | TAK1/TAB1 | TGF-beta-activated kinase 1 | Transforming growth factor-beta-activated kinase 1 (TAK1)
Type:Protein
Mol. Mass.:67199.89
Organism:Homo sapiens (Human)
Description:O43318
Residue:606
Sequence:
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN
ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI
ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ
KRQGTS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50209673
n/a
NameBDBM50209673
Synonyms:CHEMBL3883761
TypeSmall organic molecule
Emp. Form.C25H28N6O3
Mol. Mass.460.5282
SMILESCOc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1Oc1ccccc1NC(=O)C=C
Structure
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