Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50209869 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1634233 (CHEMBL3877025) |
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Ki | 24±n/a nM |
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Citation | Kumar, R; Bua, S; Ram, S; Del Prete, S; Capasso, C; Supuran, CT; Sharma, PK Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors. Bioorg Med Chem25:1286-1293 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50209869 |
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n/a |
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Name | BDBM50209869 |
Synonyms: | CHEMBL3884021 |
Type | Small organic molecule |
Emp. Form. | C17H14N4O2S2 |
Mol. Mass. | 370.449 |
SMILES | Cc1ccc(cc1)-c1csc2nc(nn12)-c1ccc(cc1)S(N)(=O)=O |
Structure |
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