| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
|---|
| Ligand | BDBM50209873 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1634233 (CHEMBL3877025) |
|---|
| Ki | 85±n/a nM |
|---|
| Citation |  Kumar, R; Bua, S; Ram, S; Del Prete, S; Capasso, C; Supuran, CT; Sharma, PK Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors. Bioorg Med Chem25:1286-1293 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 12 |
|---|
| Name: | Carbonic anhydrase 12 |
|---|
| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 39456.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Catalytic domain of human cloned isozyme was used in the assay |
|---|
| Residue: | 354 |
|---|
| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
|
|
|
|---|
| BDBM50209873 |
|---|
| n/a |
|---|
| Name | BDBM50209873 |
|---|
| Synonyms: | CHEMBL3885336 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H11BrN4O2S2 |
|---|
| Mol. Mass. | 435.318 |
|---|
| SMILES | NS(=O)(=O)c1ccc(cc1)-c1nn2cc(nc2s1)-c1ccc(Br)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
