Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase PLK1 | ||
| Ligand | BDBM50402023 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1634396 (CHEMBL3877188) | ||
| IC50 | 0.870000±n/a nM | ||
| Citation |  Munoz, L Non-kinase targets of protein kinase inhibitors. Nat Rev Drug Discov16:424-440 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase PLK1 | |||
| Name: | Serine/threonine-protein kinase PLK1 | ||
| Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 68277.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P53350 | ||
| Residue: | 603 | ||
| Sequence: |
| ||
| BDBM50402023 | |||
| n/a | |||
| Name | BDBM50402023 | ||
| Synonyms: | BI 6727 | VOLASERTIB | ||
| Type | Small organic molecule | ||
| Emp. Form. | C34H50N8O3 | ||
| Mol. Mass. | 618.8126 | ||
| SMILES | CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O |r,wU:2.1,22.22,wD:25.29,(-16.91,4.13,;-15.37,4.13,;-14.97,2.64,;-13.64,3.41,;-13.64,4.95,;-14.97,5.72,;-12.31,5.72,;-12.31,2.64,;-10.97,3.41,;-9.64,2.64,;-8.31,3.41,;-6.97,2.64,;-5.64,3.41,;-4.3,2.64,;-4.3,1.1,;-5.64,.33,;-6.97,1.1,;-8.31,.33,;-8.31,-1.21,;-3.22,.01,;-3.22,-1.53,;-2.13,1.1,;-.79,.33,;.54,1.1,;1.87,.33,;1.87,-1.21,;.54,-1.98,;-.79,-1.21,;3.21,-1.98,;3.21,-3.52,;4.54,-4.29,;5.88,-3.52,;7.21,-4.29,;8.54,-3.52,;8.94,-2.03,;9.71,-3.37,;5.88,-1.98,;4.54,-1.21,;-9.64,1.1,;-10.97,.33,;-12.31,1.1,;-13.64,.33,;-13.64,-1.21,;-14.97,1.1,;-16.31,.33,)| | ||
| Structure | 
| ||