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TargetFerrochelatase, mitochondrial
LigandBDBM50396483
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1634427 (CHEMBL3877219)
EC50 5012±n/a nM
Citation Munoz, L Non-kinase targets of protein kinase inhibitors. Nat Rev Drug Discov16:424-440 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ferrochelatase, mitochondrial
Name:Ferrochelatase, mitochondrial
Synonyms:4.99.1.1 | FECH | Ferrochelatase, mitochondrial | HEMH_HUMAN | Heme synthase | Protoheme ferro-lyase
Type:PROTEIN
Mol. Mass.:47876.76
Organism:Homo sapiens (Human)
Description:ChEMBL_116956
Residue:423
Sequence:
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
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  Blast E-value cutoff:
BDBM50396483
n/a
NameBDBM50396483
Synonyms:PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemurafenib | US11332479, Compound Vemurafenib | US11492357, Control | US9388165, Reference, Vemurafenib (PLX-4032) | USRE47451, PLX-4032, Roche | VEMURAFENIB
TypeSmall organic molecule
Emp. Form.C23H18ClF2N3O3S
Mol. Mass.489.922
SMILESCCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Structure
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