| Reaction Details |
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 | Report a problem with these data |
| Target | Pyruvate kinase |
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| Ligand | BDBM50210348 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1634707 |
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| IC50 | 3.0±n/a nM |
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| Citation |  Labrière, C; Gong, H; Finlay, BB; Reiner, NE; Young, RN Further investigation of inhibitors of MRSA pyruvate kinase: Towards the conception of novel antimicrobial agents. Eur J Med Chem125:1-13 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pyruvate kinase |
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| Name: | Pyruvate kinase |
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| Synonyms: | KPYK_STAAR | PK | pyk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63128.44 |
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| Organism: | Staphylococcus aureus (strain MRSA252) |
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| Description: | ChEMBL_1434805 |
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| Residue: | 585 |
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| Sequence: | MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKI
VAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSY
ILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRF
GIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIEEILEVSDGLM
VARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANA
IYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIG
ISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVV
KKGRKSTDALLNNAVATAVETGRVTNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQ
GIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPS
AIVGLEKGIPTVVGVEKAVKNISNNVLVTIDAAQGKIFEGYANVL
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| BDBM50210348 |
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| n/a |
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| Name | BDBM50210348 |
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| Synonyms: | CHEMBL3949603 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10Br2N4O |
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| Mol. Mass. | 434.085 |
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| SMILES | Brc1ccc2[nH]c(cc2c1)C(=O)Nc1nc2cc(Br)ccc2[nH]1 |
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| Structure | 
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