Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50159089 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1635860 (CHEMBL3878758) |
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Ki | 2.7±n/a nM |
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Citation | Kim, T; Yang, HY; Park, BG; Jung, SY; Park, JH; Park, KD; Min, SJ; Tae, J; Yang, H; Cho, S; Cho, SJ; Song, H; Mook-Jung, I; Lee, J; Pae, AN Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease. Eur J Med Chem125:1172-1192 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 18834.74 |
Organism: | Homo sapiens (Human) |
Description: | P30536 |
Residue: | 169 |
Sequence: | MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAM
GYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAA
ATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
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BDBM50159089 |
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n/a |
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Name | BDBM50159089 |
Synonyms: | CHEMBL180523 | N,N-Dibutyl-2-[6,8-dichloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide |
Type | Small organic molecule |
Emp. Form. | C23H26Cl3N3O |
Mol. Mass. | 466.831 |
SMILES | CCCCN(CCCC)C(=O)Cc1c(nc2c(Cl)cc(Cl)cn12)-c1ccc(Cl)cc1 |
Structure |
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