Reaction Details |
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Target | Quinolone resistance protein NorA |
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Ligand | BDBM50211228 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1636257 (CHEMBL3879155) |
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IC50 | 2020±n/a nM |
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Citation | Buonerba, F; Lepri, S; Goracci, L; Schindler, BD; Seo, SM; Kaatz, GW; Cruciani, G Improved Potency of Indole-Based NorA Efflux Pump Inhibitors: From Serendipity toward Rational Design and Development. J Med Chem60:517-523 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Quinolone resistance protein NorA |
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Name: | Quinolone resistance protein NorA |
Synonyms: | NORA_STAAU | norA |
Type: | PROTEIN |
Mol. Mass.: | 42273.03 |
Organism: | Staphylococcus aureus |
Description: | ChEMBL_961221 |
Residue: | 388 |
Sequence: | MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT
LADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADIS
PSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDP
KKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDI
SIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISF
VVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIY
MAIGVSLAGVVIVLIEKQHRAKLKEQNM
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BDBM50211228 |
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n/a |
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Name | BDBM50211228 |
Synonyms: | CHEMBL3956740 |
Type | Small organic molecule |
Emp. Form. | C38H40N6O5 |
Mol. Mass. | 660.7614 |
SMILES | CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCCCCNCc3ccc(Oc4nnnn4-c4ccccc4)c(OC)c3)cc12 |
Structure |
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