| Reaction Details |
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 | Report a problem with these data |
| Target | Monoacylglycerol lipase ABHD6 |
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| Ligand | BDBM50211268 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1636269 |
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| IC50 | 158±n/a nM |
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| Citation |  Deng, H; Kooijman, S; van den Nieuwendijk, AM; Ogasawara, D; van der Wel, T; van Dalen, F; Baggelaar, MP; Janssen, FJ; van den Berg, RJ; den Dulk, H; Cravatt, BF; Overkleeft, HS; Rensen, PC; van der Stelt, M Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. J Med Chem60:428-440 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoacylglycerol lipase ABHD6 |
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| Name: | Monoacylglycerol lipase ABHD6 |
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| Synonyms: | 2-arachidonoylglycerol hydrolase | ABHD6 | ABHD6_HUMAN | Abhydrolase domain-containing protein 6 | Monoacylglycerol lipase ABHD6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38341.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105457 |
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| Residue: | 337 |
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| Sequence: | MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQF
CYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLS
IDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYST
DNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHN
NFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVEL
LENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD
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| BDBM50211268 |
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| n/a |
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| Name | BDBM50211268 |
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| Synonyms: | CHEMBL3912754 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26F2N4O3 |
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| Mol. Mass. | 504.5278 |
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| SMILES | O[C@@H]1CC[C@H](Cc2ccccc2)N(C1)C(=O)n1ncc(n1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1 |r| |
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| Structure | 
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