| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol lipase-alpha |
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| Ligand | BDBM50211266 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1636271 |
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| IC50 | 7.9±n/a nM |
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| Citation |  Deng, H; Kooijman, S; van den Nieuwendijk, AM; Ogasawara, D; van der Wel, T; van Dalen, F; Baggelaar, MP; Janssen, FJ; van den Berg, RJ; den Dulk, H; Cravatt, BF; Overkleeft, HS; Rensen, PC; van der Stelt, M Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. J Med Chem60:428-440 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol lipase-alpha |
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| Name: | Diacylglycerol lipase-alpha |
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| Synonyms: | DGL-alpha | DGLA_MOUSE | Dagla | Kiaa0659 | Neural stem cell-derived dendrite regulator | Nsddr | Sn1-specific diacylglycerol lipase alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 115371.22 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_101098 |
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| Residue: | 1044 |
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| Sequence: | MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGR
GYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLT
QYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTY
NLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGL
VLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSHEMLRYKEVCYYMLFAL
AAYGWPMYLMRKPTCGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLD
ENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVE
GHRGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAI
LSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQ
LLDVLQRSTKPKWRIIVGATKCIPKSELPEDQVEVTTLASTRLWTHPSDLTIALSASTPL
YPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGL
NKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPLPTGLALELPATEHR
NSSVRSKSQSEMSLEGFSEGRLLSPVAAASAARQDPVELLLLSTQERLAAELQSRRAPLA
TMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRT
ELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSATIEEEEAAGGSEGGGVAPRGELALH
NGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMMVPESPTSDYTEGPKSPSQQEI
LLRAQFEPNLVPKPPRLFAGSAEPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLATDK
IRTSTPTGHGASPTKQDDLVISAR
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| BDBM50211266 |
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| n/a |
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| Name | BDBM50211266 |
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| Synonyms: | CHEMBL3906477 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26N4O |
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| Mol. Mass. | 422.5215 |
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| SMILES | O=C(N1CCCC[C@@H]1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1ccccc1 |r| |
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| Structure | 
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