| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 1/2 |
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| Ligand | BDBM50215872 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_98640 (CHEMBL708865) |
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| Ki | 92±n/a nM |
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| Citation |  Chambers, RJ; Antognoli, GW; Cheng, JB; Marfat, A; Pillar, JS; Shirley, JT; Watson, JW Development of new chromanol antagonists of leukotriene D4. Bioorg Med Chem Lett8:1791-6 (1998) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteinyl leukotriene receptor 1/2 |
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| Name: | Cysteinyl leukotriene receptor 1/2 |
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| Synonyms: | Cysteinyl leukotriene receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 98640 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cysteinyl leukotriene receptor 1 |
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| Synonyms: | CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38565.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271 |
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| Residue: | 337 |
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| Sequence: | MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
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| Component 2 |
| Name: | Cysteinyl leukotriene receptor 2 |
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| Synonyms: | CLTR2_HUMAN | CYSLT2 | CYSLT2R | CYSLTR2 | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39657.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75 |
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| Residue: | 346 |
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| Sequence: | MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSI
YVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYV
NMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQ
NGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRV
SHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACF
NPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
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| BDBM50215872 |
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| n/a |
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| Name | BDBM50215872 |
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| Synonyms: | CHEMBL50399 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22FNO5S |
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| Mol. Mass. | 479.52 |
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| SMILES | [H][C@@]1(C)Oc2ccc(OCc3nc4cc(F)ccc4s3)cc2[C@]([H])(O)[C@@H]1Cc1cccc(c1)C(O)=O |
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| Structure | 
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