Reaction Details |
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Target | Lanosterol 14-alpha demethylase |
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Ligand | BDBM25817 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_151526 (CHEMBL762239) |
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IC50 | 127±n/a nM |
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Citation | Tsukuda, T; Shiratori, Y; Watanabe, M; Ontsuka, H; Hattori, K; Shirai, M; Shimma, N Modeling, synthesis and biological activity of novel antifungal agents (1). Bioorg Med Chem Lett8:1819-24 (1998) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Lanosterol 14-alpha demethylase |
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Name: | Lanosterol 14-alpha demethylase |
Synonyms: | CP51A_HUMAN | CYP51 | CYP51A1 | CYPLI | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14α-demethylase (CYP51) | Sterol 14-alpha demethylase |
Type: | Protein |
Mol. Mass.: | 56817.21 |
Organism: | Homo sapiens (Human) |
Description: | Q16850 |
Residue: | 503 |
Sequence: | MLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKS
PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNS
KNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK
EYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWL
LPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE
VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDL
NLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD
FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFP
TVNYTTMIHTPENPVIRYKRRSK
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BDBM25817 |
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n/a |
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Name | BDBM25817 |
Synonyms: | 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol | CHEMBL106 | Diflucan | Fluconazole | Fluconazole (f) | Fungata | Triflucan | US10221160, Fluconazole | US11247981, Example Fluconazole | US9138393, Fluconazole | US9144538, Fluconazole | US9221791, Fluconazole | US9556143, Fluconazole | cid_3365 |
Type | Small organic molecule |
Emp. Form. | C13H12F2N6O |
Mol. Mass. | 306.2708 |
SMILES | OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F |
Structure |
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