| Reaction Details |
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 | Report a problem with these data |
| Target | Neurotensin receptor type 1/2 |
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| Ligand | BDBM50086639 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_144288 (CHEMBL754789) |
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| Ki | 28±n/a nM |
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| Citation |  Lundquist, JT; Dix, TA Preparation and receptor binding affinities of cyclic C-terminal neurotensin (8-13) and (9-13) analogues. Bioorg Med Chem Lett9:2579-82 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neurotensin receptor type 1/2 |
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| Name: | Neurotensin receptor type 1/2 |
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| Synonyms: | Neurotensin receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 144284 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Neurotensin receptor type 2 |
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| Synonyms: | Levocabastine-sensitive neurotensin receptor | NT-R-2 | NTR2 | NTR2 receptor | NTR2_HUMAN | NTSR2 | Neurotensin receptor | Neurotensin receptor 2 | Neurotensin receptor type 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45404.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1281495 |
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| Residue: | 410 |
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| Sequence: | METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKA
RAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAY
ATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHEL
ETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQV
PSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLR
AIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNA
VSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
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| Component 2 |
| Name: | Neurotensin receptor type 1 |
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| Synonyms: | Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46278.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1453811 |
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| Residue: | 418 |
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| Sequence: | MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI
YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM
PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM
SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN
TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH
GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN
PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
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| BDBM50086639 |
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| n/a |
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| Name | BDBM50086639 |
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| Synonyms: | (S)-2-{(2S,3S)-2-[(S)-2-{[(S)-1-((S)-2-Amino-5-guanidino-pentanoyl)-pyrrolidine-2-carbonyl]-amino}-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid | (S)-2-{(2S,4S)-2-[(S)-2-{[1-((2S,3S)-2-Amino-5-guanidino-pentanoyl)-pyrrolidine-2-carbonyl]-amino}-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid | Arg-Pro-Tyr-Ile-Leu | CHEMBL48981 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H52N8O7 |
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| Mol. Mass. | 660.8047 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(O)=O |
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| Structure | 
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