| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
|---|
| Ligand | BDBM50218259 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_195885 (CHEMBL799007) |
|---|
| IC50 | 23±n/a nM |
|---|
| Citation |  Buckley, G; Cooper, N; Dyke, HJ; Galleway, F; Gowers, L; Gregory, JC; Hannah, DR; Haughan, AF; Hellewell, PG; Kendall, HJ; Lowe, C; Maxey, R; Montana, JG; Naylor, R; Picken, CL; Runcie, KA; Sabin, V; Tuladhar, BR; Warneck, JB 7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma. Bioorg Med Chem Lett10:2137-40 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
|---|
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
|---|
| Synonyms: | Dpde1 | PDE4C_RAT | Pde4c |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60038.21 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_104732 |
|---|
| Residue: | 536 |
|---|
| Sequence: | NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQ
QAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSR
SGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQT
DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYL
LTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVID
MVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPL
PLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD
LVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
|
|
|
|---|
| BDBM50218259 |
|---|
| n/a |
|---|
| Name | BDBM50218259 |
|---|
| Synonyms: | CHEMBL67898 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14Cl2N2O3 |
|---|
| Mol. Mass. | 365.211 |
|---|
| SMILES | CCc1cc2c(ccc(OC)c2o1)C(=O)Nc1c(Cl)cncc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
