Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM50218403

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_62585 (CHEMBL673113)

6.3±n/a nM

Citation

Austin, NE; Avenell, KY; Boyfield, I; Branch, CL; Hadley, MS; Jeffrey, P; Johnson, CN; Macdonald, GJ; Nash, DJ; Riley, GJ; Smith, AB; Stemp, G; Thewlis, KM; Vong, AK; Wood, M Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor. Bioorg Med Chem Lett10:2553-5 (2000) [PubMed]

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM50218403

n/a

Name

BDBM50218403

Synonyms:

CHEMBL86032

Type

Small organic molecule

Emp. Form.

C28H32N4O3

Mol. Mass.

472.5787

SMILES

O=C(N[C@H]1CC[C@H](CCN2CCc3ccc(cc3CC2)C#N)CC1)c1ccc2OCC(=O)Nc2c1 |wU:3.2,wD:6.6,(21.89,-13.31,;21.91,-11.77,;20.56,-11,;19.25,-11.77,;19.25,-13.31,;17.92,-14.08,;16.57,-13.31,;15.22,-14.09,;15.21,-15.64,;13.88,-16.41,;12.54,-15.64,;11.11,-16.22,;10.65,-17.69,;9.11,-17.81,;8.43,-19.19,;9.34,-20.47,;10.87,-20.35,;11.53,-18.95,;13.05,-19.07,;14.1,-17.95,;8.71,-21.89,;8.1,-23.32,;16.57,-11.77,;17.9,-11,;23.25,-11,;23.25,-9.46,;24.59,-8.69,;25.92,-9.46,;27.25,-8.69,;28.59,-9.46,;28.59,-11,;29.94,-11.77,;27.25,-11.77,;25.92,-11,;24.59,-11.77,)|

Structure