| Reaction Details |
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 | Report a problem with these data |
| Target | Thioredoxin reductase 3 |
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| Ligand | BDBM50218804 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210563 (CHEMBL816515) |
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| IC50 | 4500±n/a nM |
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| Citation |  Wipf, P; Hopkins, TD; Jung, JK; Rodriguez, S; Birmingham, A; Southwick, EC; Lazo, JS; Powis, G New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead. Bioorg Med Chem Lett11:2637-41 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thioredoxin reductase 3 |
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| Name: | Thioredoxin reductase 3 |
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| Synonyms: | TGR | TGR | TRXR3 | TRXR3_HUMAN | TXNRD3 | Thioredoxin and glutathione reductase | Thioredoxin reductase 3 | Thioredoxin reductase TR2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70543.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104858 |
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| Residue: | 642 |
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| Sequence: | MERSPPQSPGPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLV
GLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTV
PNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGK
KVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRH
NWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQ
FVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDV
TVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEG
TETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDIL
EDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKK
ENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAM
KCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCG
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| BDBM50218804 |
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| n/a |
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| Name | BDBM50218804 |
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| Synonyms: | CHEMBL89475 | SCH-49209 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14O7 |
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| Mol. Mass. | 366.321 |
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| SMILES | [H][C@]12O[C@@]1([H])C1(Oc3cccc4cccc(O1)c34)[C@@]13O[C@@]1([C@@H](O)C=CC3=O)[C@H]2O |c:28| |
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| Structure | 
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