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TargetThioredoxin reductase 3
LigandBDBM50218846
Substrate/Competitorn/a
Meas. Tech.ChEMBL_210422 (CHEMBL811694)
IC50>50000±n/a nM
Citation Wipf, PHopkins, TDJung, JKRodriguez, SBirmingham, ASouthwick, ECLazo, JSPowis, G New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead. Bioorg Med Chem Lett11:2637-41 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thioredoxin reductase 3
Name:Thioredoxin reductase 3
Synonyms:TGR | TGR | TRXR3 | TRXR3_HUMAN | TXNRD3 | Thioredoxin and glutathione reductase | Thioredoxin reductase 3 | Thioredoxin reductase TR2
Type:PROTEIN
Mol. Mass.:70543.23
Organism:Homo sapiens (Human)
Description:ChEMBL_104858
Residue:642
Sequence:
MERSPPQSPGPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLV
GLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTV
PNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGK
KVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRH
NWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQ
FVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDV
TVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEG
TETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDIL
EDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKK
ENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAM
KCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50218846
n/a
NameBDBM50218846
Synonyms:CHEMBL329895
TypeSmall organic molecule
Emp. Form.C31H19ClO5
Mol. Mass.506.933
SMILESClc1cccc(c1)-c1ccc(COc2cccc3c2C(=O)C=CC32Oc3cccc4cccc(O2)c34)o1 |c:23|
Structure
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