| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
|---|
| Ligand | BDBM50219815 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_157216 (CHEMBL769540) |
|---|
| IC50 | 20±n/a nM |
|---|
| Citation |  Buckley, GM; Cooper, N; Dyke, HJ; Galleway, FP; Gowers, L; Haughan, AF; Kendall, HJ; Lowe, C; Maxey, R; Montana, JG; Naylor, R; Oxford, J; Peake, JC; Picken, CL; Runcie, KA; Sabin, V; Sharpe, A; Warneck, JB 8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma. Bioorg Med Chem Lett12:1613-5 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
|---|
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
|---|
| Synonyms: | Dpde1 | PDE4C_RAT | Pde4c |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60038.21 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_104732 |
|---|
| Residue: | 536 |
|---|
| Sequence: | NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQ
QAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSR
SGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQT
DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYL
LTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVID
MVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPL
PLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD
LVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
|
|
|
|---|
| BDBM50219815 |
|---|
| n/a |
|---|
| Name | BDBM50219815 |
|---|
| Synonyms: | CHEMBL43570 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H9Cl2F3N4O2 |
|---|
| Mol. Mass. | 405.159 |
|---|
| SMILES | COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2[nH]c(nc12)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
