| Reaction Details |
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 | Report a problem with these data |
| Target | Thrombin and coagulation factor X |
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| Ligand | BDBM50215310 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_209399 |
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| Ki | 6.5±n/a nM |
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| Citation |  Cui JJ; Araldi GL; Reiner JE; Reddy KM; Kemp SJ; Ho JZ; Siev DV; Mamedova L; Gibson TS; Gaudette JA; Minami NK; Anderson SM; Bradbury AE; Nolan TG; Semple JE Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates. Bioorg Med Chem Lett 12:2925-30 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thrombin and coagulation factor X |
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| Name: | Thrombin and coagulation factor X |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | Prothrombin precursor | Thrombin heavy chain | Thrombin light chain |
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| Type: | Protein |
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| Mol. Mass.: | 70029.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00734 |
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| Residue: | 622 |
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| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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| BDBM50215310 |
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| n/a |
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| Name | BDBM50215310 |
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| Synonyms: | CHEMBL97869 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22ClN5O4S |
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| Mol. Mass. | 499.97 |
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| SMILES | Cc1ccc(NS(=O)(=O)Cc2ccc(Cl)cc2)c(=O)n1CC(=O)NCc1ccc2[nH]cnc2c1 |
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| Structure | 
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