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TargetCorticotropin-releasing factor receptor 1/2
LigandBDBM50218684
Substrate/Competitorn/a
Meas. Tech.ChEMBL_217368 (CHEMBL822880)
Ki 223±n/a nM
Citation Hartz, RAGilligan, PJNanda, KKTebben, AJFitzgerald, LWMiller, K Synthesis and evaluation of imidazo[1,5-a]pyrazines as corticotropin releasing hormone receptor ligands. Bioorg Med Chem Lett12:291-4 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Corticotropin-releasing factor receptor 1/2
Name:Corticotropin-releasing factor receptor 1/2
Synonyms:Corticotropin releasing factor receptor
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 217368
Components:This complex has 2 components.
Component 1
Name:Corticotropin-releasing factor receptor 1
Synonyms:CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:47870.75
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat cortex homogenate.
Residue:415
Sequence:
MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
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Component 2
Name:Corticotropin-releasing factor receptor 2
Synonyms:CRF-R-2 | CRF-R2 | CRF2 Beta | CRFR-2 | CRFR2_RAT | CRH-R-2 | CRH-R2 | Corticotropin releasing factor receptor | Corticotropin-releasing factor receptor 2 | Corticotropin-releasing hormone receptor 2 | Crf2r | Crhr2
Type:Enzyme Catalytic Domain
Mol. Mass.:47697.09
Organism:RAT
Description:CRF2 Beta 0 RAT::P47866
Residue:411
Sequence:
MDAALLLSLLEANCSLALAEELLLDGWGEPPDPEGPYSYCNTTLDQIGTCWPQSAPGALV
ERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIIN
YLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNITWFLLQLIDHEVHEGN
EVWCRCVTTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIV
AWAVGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTS
ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYC
FFNGEVRSALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
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BDBM50218684
n/a
NameBDBM50218684
Synonyms:CHEMBL99741
TypeSmall organic molecule
Emp. Form.C20H25Cl2N5
Mol. Mass.406.352
SMILESCCCN(CCC)c1nccn2c(Nc3ccc(Cl)cc3Cl)nc(CC)c12
Structure
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