Reaction Details |
| Report a problem with these data |
Target | Corticotropin-releasing factor receptor 1/2 |
---|
Ligand | BDBM50220482 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_50968 (CHEMBL666049) |
---|
Ki | 16±n/a nM |
---|
Citation | Arvanitis, AG; Rescinito, JT; Arnold, CR; Wilde, RG; Cain, GA; Sun, JH; Yan, JS; Teleha, CA; Fitzgerald, LW; McElroy, J; Zaczek, R; Hartig, PR; Grossman, S; Arneric, SP; Gilligan, PJ; Olson, RE; Robertson, DW Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands. Bioorg Med Chem Lett13:125-8 (2003) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Corticotropin-releasing factor receptor 1/2 |
---|
Name: | Corticotropin-releasing factor receptor 1/2 |
Synonyms: | Corticotropin releasing factor receptor |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 217368 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Corticotropin-releasing factor receptor 1 |
Synonyms: | CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 47870.75 |
Organism: | Rattus norvegicus (rat) |
Description: | Receptor binding assays were performed using rat cortex homogenate. |
Residue: | 415 |
Sequence: | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
|
|
|
Component 2 |
Name: | Corticotropin-releasing factor receptor 2 |
Synonyms: | CRF-R-2 | CRF-R2 | CRF2 Beta | CRFR-2 | CRFR2_RAT | CRH-R-2 | CRH-R2 | Corticotropin releasing factor receptor | Corticotropin-releasing factor receptor 2 | Corticotropin-releasing hormone receptor 2 | Crf2r | Crhr2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 47697.09 |
Organism: | RAT |
Description: | CRF2 Beta 0 RAT::P47866 |
Residue: | 411 |
Sequence: | MDAALLLSLLEANCSLALAEELLLDGWGEPPDPEGPYSYCNTTLDQIGTCWPQSAPGALV
ERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIIN
YLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNITWFLLQLIDHEVHEGN
EVWCRCVTTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIV
AWAVGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTS
ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYC
FFNGEVRSALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
|
|
|
BDBM50220482 |
---|
n/a |
---|
Name | BDBM50220482 |
Synonyms: | CHEMBL23788 |
Type | Small organic molecule |
Emp. Form. | C18H17Cl2F2N3 |
Mol. Mass. | 384.25 |
SMILES | CCCC(C)n1c(nc2c(ccnc12)-c1ccc(Cl)cc1Cl)C(F)F |
Structure |
|